{"id":71,"date":"2017-10-17T04:23:50","date_gmt":"2017-10-17T04:23:50","guid":{"rendered":"https:\/\/www.saratoga.com\/healing-health-wellness\/?p=71"},"modified":"2023-04-12T20:44:57","modified_gmt":"2023-04-12T20:44:57","slug":"gluten-the-evil-doer-or-guilt-by-association-microbiome","status":"publish","type":"post","link":"https:\/\/www.saratoga.com\/healing-health-wellness\/2017\/10\/gluten-the-evil-doer-or-guilt-by-association-microbiome\/","title":{"rendered":"Gluten- The Evil-Doer or Guilt by Association?"},"content":{"rendered":"
Is Gluten Always Bad?<\/strong><\/p>\n Gluten<\/a> has become a dirty word in the diet and health culture industry.<\/p>\n There\u2019s reason for this.<\/p>\n I\u2019ve written previously on how this protein found in wheat, barley, rye, and other related grains may indeed trigger a negative response in certain individuals. (1,<\/a> 2,<\/a> 3<\/a>, 4<\/a>, 5<\/a>) Under specific health contexts, accompanied by proper testing and\/or clinical observations to warrant its association to discomfort, it is probably wise to remove it\u2026at least until the underlying cause is addressed and health is restored.<\/p>\n In other cases, as with those with celiac disease, gluten may be the known perpetrator, contributor, and trigger of unwanted systemic effects and gastrointestinal harm. Therefore, individuals with this diagnosis, which has a genetic component, would be wise to avoid its ingestion\u2026 throughout the rest of their life. This \u201cextreme\u201d measure is to decrease the possibility of causing harm to their bellies\u2019 lining and bodies, as celiac disease is a disorder<\/a> of malabsorption as well as an abnormal immune reaction to gluten.<\/p>\n Lately, numerous experts in health have deemed gluten as a major cause and contributor to a wide range of chronic health diseases. In fact, many have proclaimed that the grain, regardless of quality and food prep, should never be eaten\u2026 ever again\u2026by anyone. (Hmmm\u2026shades of butter bashing<\/a>?)<\/p>\n I admit, I previously had a bit of bias against<\/a> gluten. In the past, I was quick to point out that it had no place on anyone\u2019s plate. I even explored in several blogs the ways it negatively impacted the body.<\/p>\n It is true that science does support that cessation of gluten in the diet has been helpful in mitigating symptoms of various disease processes\u2026but why?<\/p>\n <\/p>\n A Deeper Dive into Why Someone May React to Gluten Recently, I updated my viewpoint on gluten. I wrote a two-part series that explored gluten\u2019s association to conditions other than celiac disease.<\/p>\n In Part I, I explored:<\/p>\n In Part II<\/a>, I discussed other reasons that gluten may be more of a witness at the crime scene rather than the criminal. These included:<\/p>\n As you know, I love the topic of belly bugs<\/a>. As I was exploring more about the microbiome and its interaction with essential oils<\/a> for my rally presentation (you can get a preview of that here<\/a>), I also dove into its role in gluten responses.<\/p>\n Here\u2019s what I found.<\/p>\n <\/p>\n Gluten and the Microbiome<\/strong><\/p>\n Some studies have suggested that the differences in our microbiome, and these responses of the critters that line our insides, may be the key factor in if one has negative responses to gluten consumption. Below are a few articles I found on this topic. You can probably get a gist of what the bottom line was by the titles. For some, I included an excerpt:<\/p>\n This article, Intestinal Microbiota and Celiac Disease: Cause, Consequence or Co-Evolution?<\/a>, was particularly intriguing. The authors detail how the microbiome and host genetics interact. Importantly, they point out all the factors that influence the microbiome makeup to begin with that would be the basis of a response! (This is similar to the first article on celiac disease):<\/p>\n It is widely recognized that the intestinal microbiota plays a role in the initiation and perpetuation of intestinal inflammation in numerous chronic conditions. Most studies report intestinal dysbiosis in celiac disease (CD) patients, untreated and treated with a gluten-free diet (GFD), compared to healthy controls. CD patients with gastrointestinal symptoms are also known to have a different microbiota compared to patients with dermatitis herpetiformis and controls, suggesting that the microbiota is involved in disease manifestation. Furthermore, a dysbiotic microbiota seems to be associated with persistent gastrointestinal symptoms in treated CD patients, suggesting its pathogenic implication in these particular cases. GFD per se influences gut microbiota composition, and thus constitutes an inevitable confounding factor in studies conducted in CD patients. To improve our understanding of whether intestinal dysbiosis is the cause or consequence of disease, prospective studies in healthy infants at family risk of CD are underway. These studies have revealed that the CD host genotype selects for the early colonizers of the infant\u2019s gut, which together with environmental factors (e.g., breast-feeding, antibiotics, etc.) could influence the development of oral tolerance to gluten. Indeed, some CD genes and\/or their altered expression play a role in bacterial colonization and sensing. In turn, intestinal dysbiosis could promote an abnormal response to gluten or other environmental CD-promoting factors (e.g., infections) in predisposed individuals. Here, we review the current knowledge of host-microbe interactions and how host genetics\/epigenetics and environmental factors shape gut microbiota and may influence disease risk. We also summarize the current knowledge about the potential mechanisms of action of the intestinal microbiota and specific components that affect CD pathogenesis.<\/em><\/p>\n Processing of grains is also a consideration. This is not just in relation to the decrease in its quality and resultant inflammation or nutrient deficiencies that can result. More importantly, it may be its connection to how it modulates the microbiome. Here is a summary of 2015 article in Medical Hypotheses<\/em><\/a>:<\/p>\n While gluten and wheat must be absolutely avoided in coeliac disease and allergy, respectively, nutritional recommendations are largely more confused about non-coeliac wheat\/gluten sensitivity (NCWGS). Today, some even recommend avoiding all cereal-based foods. In this paper, the increased NCWGS prevalence is hypothesized to parallel the use of more and more drastic processes applied to the original wheat grain. First, a parallel between gluten-related disorders and wheat processing and consumption evolution is briefly proposed. Notably, increased use of exogenous vital gluten is considered. Drastic processing in wheat technology are mainly grain fractionation and refining followed by recombination and salt, sugars and fats addition, being able to render ultra-processed cereal-based foods more prone to trigger chronic low-grade inflammation. Concerning bread, intensive kneading and the choice of wheat varieties with high baking quality may have rendered gluten less digestible, moving digestion from pancreatic to intestinal proteases. The hypothesis of a gluten resistant fraction reaching colon and interacting with microflora is also considered in relation with increased inflammation. Besides, wheat flour refining removes fiber co-passenger which have potential anti-inflammatory property able to protect digestive epithelium. Finally, some research tracks are proposed, notably the comparison of NCWGS prevalence in populations consuming ultra-versus minimally-processed cereal-based food. (<\/em>Med Hypotheses. 2015 Dec;85(6):934-9. doi: 10.1016\/j.mehy.2015.09.007.)<\/em><\/p>\n \u00a0 Conclusion<\/strong><\/p>\n If you are known to be gluten-sensitive and\/or have celiac disease, it would be wise to stay away from gluten until otherwise informed by your trusted health care provider.<\/p>\n However, I believe the world is confusing a trigger with a cause. Even those with celiac are born with the predisposition, not the actual disease.<\/p>\n What if it\u2019s deemed an evil-doer like cholesterol<\/a>, but is guilty by association, by a world of inflamed guts, resulting unhappy critters in our bellies, and a nocebo<\/a> effect?<\/p>\n In fact, the renowned researcher who is credited<\/a> for providing evidence for the \u201cleaky gut\u201d\/gluten link himself stated that the issue is complex and dependent on the individual<\/a>.<\/p>\n Will we one-day have a probiotic for celiac disease<\/a> or a pill to alleviate its exposure?<\/p>\n\u00a0<\/strong><\/p>\n
\n<\/strong><\/p>\n\n
\n
\n
\n
<\/strong><\/p>\n